VSpots is a new approach to subtomogram averaging performed in the context of the original tilt series. The procedure is being developed as a module of our in-house subtomogram averaging (StA) software package Dynamo.
The core functionality of Vspots is the characterization of the interplay between tomographic alignment and subtomogram refinement. Vsopts aims to increase of the resolution in the attained averages. In addition, the module will complements Dynamo with a rich library of general (i.e., non STA specific) tools for cryo electron tomography, including tilt series alignment, tomogram reconstruction, annotation and archiving of complex workflows.